The transmission of electrical impulses in nerve and muscle cells depends fundamentally on the operation of specific ion channels in their membranes. Recent technical advances in electrical recording from cell membranes have permitted the analysis of the properties of single ion channels and the measurement of gating currents. The results have revealed considerable complexities, in particular in the operation of voltage‐gated sodium channels, and in the relationships between the several open and closed states of the channels. An important new development (...) is the cloning and analysis of the structural genes for the acetylcholine receptor and sodium channel protein, which promises to yield fresh insights into the functioning of these proteins. (shrink)

The large size of the individual axons in the motor nerves of certain invertebrates has facilitated technical approaches that were not feasible elsewhere. A brief account is given of the way in which giant axons have taken and held the lead in research on the mechanism of conduction.

In this essay we contend that traditional theories of argument are consonant with and enrich the project of postmodernity. Reading postmodernity as ‘a rhetoric’ underscores how the process of discursively resolving conflicts is occasionally threatened by politically motivated efforts to misuse the methods of argument; it alerts us to the egregious acts that are and can be performed ‘in the name of,’ but not because of, rationality. Postmodernity is thus an attempt by a new generation of theorists to recast and (...) draw attention to perennial philosophical problems in the context of contemporary political difficulties. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This book inquires into the swarm of ontological, epistemological, and ethical questions provoked by psychedelic experience in the context of global ecological crisis. Richard M. Doyle is professor of English and science, technology, and society at Pennsylvania State University. He is the author of On Beyond Living and Wetwares.

This book offers a thorough reanalysis of Charles Darwin's Origin of Species, which for many people represents the work that alone gave rise to evolutionism. Of course, scholars today know better than that. Yet, few resist the temptation of turning to the Origin in order to support it or reject it in light of their own work. Apparently, Darwin fills the mythical role of a founding figure that must either be invoked or repudiated. The book is an invitation (...) to move beyond what is currently expected of Darwin's magnum opus. Once the rhetorical varnish of Darwin's discourses is removed, one discovers a work of remarkably indecisive conclusions. The book comprises two main theses: The Origin of Species never remotely achieved the theoretical unity to which it is often credited. Rather, Darwin was overwhelmed by a host of phenomena that could not fit into his narrow conceptual framework. In the Origin of Species, Darwin failed at completing the full conversion to evolutionism. Carrying many ill-designed intellectual tools of the 17th and 18th centuries, Darwin merely promoted a special brand of evolutionism, one that prevented him from taking the decisive steps toward an open and modern evolutionism. It makes an interesting read for biologists, historians and philosophers alike. (shrink)

To most people through history it has always seemed obvious that the teeming diversity of life, the uncanny perfection with which living organisms are equipped to survive and multiply, and the bewildering complexity of living machinery, can only have come about through divine creation. Yet repeatedly it has occurred to isolated thinkers that there might be an alternative to supernatural creation.

Economics has developed into one of the most specialised social sciences. Yet at the same time, it shares its subject matter with other social sciences and humanities and its method of analysis has developed in close correspondence with the natural and life sciences. This book offers an up to date assessment of economics in relation to other disciplines. -/- This edited collection explores fields as diverse as mathematics, physics, biology, medicine, sociology, architecture, and literature, drawing from selected contributions to the (...) 2005 Annual Conference of the European Society for the History of Economic Thought (ESHET). There is currently much discussion at the leading edges of modern economics about openness to other disciplines, such as psychology and sociology. But what we see here is that economics has drawn on (as well as contributed to) other disciplines throughout its history. In this sense, in spite of the increasing specialisation within all disciplines, economics has always been an open discipline and the chapters in this volume provide a vivid illustration for this. -/- Open Economics is a testament to the intellectual vibrancy of historical research in economics. It presents the reader with a historical introduction to the disciplinary context of economics that is the first of its kind, and will appeal to practising economists and students of the discipline alike, as well as to anybody interested in economics and its position in the scientific and social scientific landscape. -/- Table of Contents -/- Introduction: Economics in relation to other disciplines Richard Arena, Sheila Dow and Matthias Klaes Part I. Economics in relation to the humanities and social sciences 1. The social science of economics Brian J. Loasby 2. Economics and literature Bruna Ingrao 3. Happiness: what Kahneman could have learnt from Pietro Verri Pier Luigi Porta Part II. Economics in relation to the life and natural sciences 4. Newtonian physics, experimental moral philosophy and the shaping of political economy Sergio Cremaschi 5. Evolutionary biology and economic behaviour: re-visiting Veblen's instinct of workmanship Mark Harrison 6. Medicine and economics in pre-classical economics Alain Clément and Ludovic Desmedt Part III. Economics and mathematics 7. Mathematics as the role model for neoclassical economics Nicola Giocoli 8. The role of econometric method in economic analysis: A reassessment of the Keynes-Tinbergen debate, 1938-43 Giovanna Garrone and Roberto Marchionatti IV. Economics and architecture 9. Economics and architecture Maurice Lagueux 10. Economic policies and urban development in Latin America Michele Alacevich and Andrea Costa V. Economics and geography 11. ‘Space’ in economic thought Giovanna Vertova 12. Economics, geography and colonialism in the writings of William Petty Hugh Goodacre Part VI. Economics and sociology 13. Economics and sociology: Gustav Schmoller and Werner Sombart on social differentiation Joachim Zweynert 14. Is Homo Oeconomicus a 'bad guy'? Isabelle This Saint-Jean -/- . (shrink)

This article extends Moleski’s discussion (in “Polanyi vs. Kuhn: Worlds Apart”) of the worldviews of Kuhn and Polanyi in two ways: by considering an evolutionary view of science as proposed by Kuhn, and byevaluating Kuhn’s notion of “paradigm change” compared to Polanyi’s work on scientific practice.

At least since Darwin's Origin of Species was published in 1859, it has increasingly become accepted that the existence of God is, intellectually, a lost cause, and that religious faith is an entirely non-rational matter--the province of those who willingly refuse to accept the dramatic advances of modern cosmology. Are belief in God and belief in science really mutually exclusive? Or, as noted philosopher of science and religion Richard Swinburne puts forth, can the very same criteria which scientists (...) use to reach theories about everything from DNA to the Big Bang be used to argue for the existence of God? In Is There a God? Swinburne presents a powerful and approachable case for the existence of God. Using the methods of scientific reasoning, Swinburne rigorously argues that science, far from replacing God, provides good grounds for belief in God. With each new discovery and advance, from black holes to quarks, superstrings to continuing evolution, science brings us closer to a complete understanding of how things work--but science can only go so far. Though it can explain much of how the universe works, science doesn't tell us why there is a universe at all. We can understand much of how life evolved, but why is there any life on earth? We can name and explicate scientific laws, but how is it that they operate in the universe? The Darwinian theory holds that the complex animal and human bodies that are here today exist because, ages ago, there were certain chemicals on earth, and given the laws of evolution, it was probable that complex organisms would emerge. But why those laws rather than any other? Why those chemicals? In Swinburne's view, the ultimate grand unifying theory is possible only by a belief in what he calls theism, acknowledging the existence of God: it was God who brought about the natural laws so that humans and animals would evolve. The watch may have been made, Swinburne asserts in reference to Richard Dawkins, with the aid of some blind screwdrivers (or even a blind watchmaking machine), but they were guided by a watchmaker with some very clear sight. At the heart of his argument is Swinburne's belief that the very success of science in showing us how deeply ordered the natural world is provides strong grounds for believing there is an even deeper cause of that order. By embracing a belief in God that acknowledges the truth in science, Swinburne's elegant argument supplies an essential spiritual element to our understanding of order and beauty, the structure beneath the chaos of the natural world. This informed and provocative volume will be essential reading for all readers of popular science, philosophy, and religion. (shrink)

This 1984 book describes the development of thought, both of Keynes and others, culminating in the publication in 1936 of Keynes' General Theory of Employment, Interest and Money. As one of Keynes' close collaborators - from December 1929, when the writing of the Treatise was nearing its completion - Richard Khan provides a uniquely insightful analysis of these events. The author starts with a brief survey of the contributions influential in forming Keynes' early ideas, and (...) moves on to explore the significance of the Quantity Theory of Money, and traces the development of Keynes' attitude towards the theory through his published books. Subsequent lectures are devoted to Keynes' Treatise on Money, and to his more popular writings as an economic adviser which marked the transition from the thinking in the Treatise to that in the General Theory which the author critically examines. The final lecture records the author's memory of his personal relationship with Keynes. (shrink)

Suppose that the human tendency to think of certain actions andomissions as morally required – a notion that surely lies at the heart of moral discourse – is a trait that has been naturallyselected for. Many have thought that from this premise we canjustify or vindicate moral concepts. I argue that this is mistaken, and defend Michael Ruse's view that the moreplausible implication is an error theory – the idea thatmorality is an illusion foisted upon us by evolution. Thenaturalistic fallacy (...) is a red herring in this debate,since there is really nothing that counts as a ‘fallacy’ at all. If morality is an illusion, it appears to followthat we should, upon discovering this, abolish moraldiscourse on pain of irrationality. I argue that thisconclusion is too hasty, and that we may be able usefullyto employ a moral discourse, warts and all, withoutbelieving in it. (shrink)

Through most of the 20th Century, the influence of Darwin on the philosophical field of ethics was negligible. Things changed noticeably in the last couple of decades or so of that century, and now “evolutionary ethics”—which had lain dormant since Darwin’s contemporary Herbert Spencer—is a lively and hotly debated topic. There are several Darwinian theses that might have bearing on moral philosophy.

A flurry of technological advances in molecular, cellular and developmental biology during the past decade has provided a clearer understanding of mechanisms underlying phenotypic diversification. Building upon such momentum, a recent paper tackles one of the foremost topics in evolution, that is the origin of species‐specific beak morphology in Darwin's finches.1 Previous work involving both domesticated and wild birds implicated a well‐known signaling pathway (i.e. bone morphogenetic proteins) and one population of progenitor cells in particular (i.e. cranial neural crest), (...) as primary factors for establishing beak size and shape. But these results were limited in their ability to explain fully the morphogenetic bases of patterned outgrowth. So in a quest to identify novel genes whose expression correlated with differences in beak anatomy among Darwin's finches, a DNA microarray approach was undertaken using tissues harvested from the Galápagos Islands. The results are striking and point to a protein called calmodulin, which is a mediator of cellular calcium signaling, as a key determinant of beak length. BioEssays 29: 1–6, 2007. © 2006 Wiley Periodicals, Inc. (shrink)

Thomas Henry Huxley recalled that after he had read Darwin’s Origin of Species, he had exclaimed to himself: “How extremely stupid not to have thought of that!” (Huxley,1900, 1: 183). It is a famous but puzzling remark. In his contribution to Francis Darwin’s Life and Letters of Charles Darwin, Huxley rehearsed the history of his engagement with the idea of transmutation of species. He mentioned the views of Robert Grant, an advocate of Lamarck, and Robert Chambers, who (...) anonymously published Vestiges of the Natural History of Creation (1844), which advanced a crude idea of transmutation. He also recounted his rejection of Agassiz’s belief that species were progressively replaced by the divine hand. He neglected altogether his friend Herbert Spencer’s early Lamarckian ideas about species development, which were also part of the long history of his encounters with the theory of descent. None of these sources moved him to adopt any version of the transmutation hypothesis. (shrink)

The legendary biologist, provocateur, and bestselling author mounts a timely and passionate defense of science and clear thinking with this career-spanning collection of essays, including twenty pieces published in the United States for the first time. For decades, Richard Dawkins has been the world's most brilliant scientific communicator, consistently illuminating the wonders of nature and attacking faulty logic. Science in the Soul brings together forty-two essays, polemics, and paeans--all written with Dawkins's characteristic erudition, remorseless wit, and unjaded awe of (...) the natural world. Though it spans three decades, this book couldn't be more timely or more urgent. Elected officials have opened the floodgates to prejudices that have for half a century been unacceptable or at least undercover. In a passionate introduction, Dawkins calls on us to insist that reason take center stage and that gut feelings, even when they don't represent the stirred dark waters of xenophobia, misogyny, or other blind prejudice, should stay out of the voting booth. And in the essays themselves, newly annotated by the author, he investigates a number of issues, including the importance of empirical evidence, and decries bad science, religion in the schools, and climate-change deniers. Dawkins has equal ardor for "the sacred truth of nature" and renders here with typical virtuosity the glories and complexities of the natural world. Woven into an exploration of the vastness of geological time, for instance, is the peculiar history of the giant tortoises and the sea turtles--whose journeys between water and land tell us a deeper story about evolution. At this moment, when so many highly placed people still question the fact of evolution, Dawkins asks what Darwin would make of his own legacy--"a mixture of exhilaration and exasperation"--and celebrates science as possessing many of religion's virtues--"explanation, consolation, and uplift"--without its detriments of superstition and prejudice. In a world grown irrational and hostile to facts, Science in the Soul is an essential collection by an indispensable author. Advance praise for Science in the Soul "The illumination of Richard Dawkins's incisive thinking on the intellectual world extends far beyond biology. What a treat to see so clearly how matter and meaning fit together, from fiction to philosophy to molecular biology, in one unified vision!"--Daniel C. Dennett, author of From Bacteria to Bach and Back: The Evolution of Minds "I thank Thor and Zeus that in their infinite wisdom they chose to make the great wordsmith of our age a great rationalist, and vice versa."--Matt Ridley, author of The Evolution of Everything: How New Ideas Emerge "In this golden age of enlightened science writing, it is stunning that no scientist has won the Nobel Prize for Literature. It is time literature's highest award be granted to a scientist whose writings have changed not just science but society. No living scientist is more deserving of such recognition than Richard Dawkins.Science in the Soul is the perfect embodiment of Nobel-quality literature."--Michael Shermer, publisher of Skeptic magazine, columnist for Scientific American, and author of The Moral Arc: How Science Makes Us Better People "Science in the Soul is packed with Dr. Dawkins's philosophy, humor, anger, and quiet wisdom, leading the reader gently but firmly to inevitable conclusions that edify and educate."--James Randi, author of The Faith Healers. (shrink)

Save for Anthropologists, few social scientists have been among the participants in the discussions about the appropriate structure of a ‘Universal Darwinism’. Yet evolutionary theorizing about cultural, social, and economic phenomena has a long tradition, going back well before Darwin. And over the past quarter century significant literatures have grown up concerned with the processes of change operating on science, technology, business organization and practice, and economic change more broadly, that are explicitly evolutionary in theoretical orientation. In each of (...) these fields of study, the broad proposition put forth by Darwin that change proceeds through a process involving variation, systematic selection, renewed variation... has proved both persuasive and powerful. On the other hand, the evolutionary processes involved in these areas differ in essential ways from those we now know are operative in the evolution of biological species. The objective of this essay is to highlight those differences, which a ‘Universal Darwinism’ needs to encompass, if it is to be broad enough to be a theory that is applicable to the evolution of human cultures as well as evolution in biology. (shrink)

In this bold work, of broad scope and rich erudition, Richard Miller sets out to reorient the philosophy of science. By questioning both positivism and its leading critics, he develops new solutions to the most urgent problems about justification, explanation, and truth. Using a wealth of examples from both the natural and the social sciences, Fact and Method applies the new account of scientific reason to specific questions of method in virtually every field of inquiry, including biology, physics, history, (...) sociology, anthropology, economics, psychology, and literary theory. Explicit and up-to-date analysis of leading alternative views and a wealth of examples make it an ideal introduction to the philosophy of science, as well as a powerful attempt to change the field. Like the works of Hempel, Reichenbach, and Nagel in an earlier generation, it will challenge, instruct, and help anyone with an interest in science and its limits. For the past quarter-century, the philosophy of science has been in a crisis brought on by the failure of the positivist project of resolving all basic methodological questions by applying absolutely general rules, valid for all fields at all times. Professor Miller presents a new view in which what counts as an explanation, a cause, a confirming test, or a compelling case for the existence of an unobservable is determined by frameworks of specific substantive principles, rationally adopted in the light of the actual history of inquiry. While the history of science has usually been the material for relativism, Professor Miller uses arguments of Darwin, Newton, Einstein, Galileo, and others both to undermine positivist conceptions of rationality and to support the positivists' optimism that important theoretical findings are often justifiable from all reasonable perspectives. (shrink)

"All art should become science and all science art; poetry and philosophy should be made one." Friedrich Schlegel's words perfectly capture the project of the German Romantics, who believed that the aesthetic approaches of art and literature could reveal patterns and meaning in nature that couldn't be uncovered through rationalistic philosophy and science alone. In this wide-ranging work, Robert J. Richards shows how the Romantic conception of the world influenced (and was influenced by) both the lives of the people who (...) held it and the development of nineteenth-century science. Integrating Romantic literature, science, and philosophy with an intimate knowledge of the individuals involved—from Goethe and the brothers Schlegel to Humboldt and Friedrich and Caroline Schelling—Richards demonstrates how their tempestuous lives shaped their ideas as profoundly as their intellectual and cultural heritage. He focuses especially on how Romantic concepts of the self, as well as aesthetic and moral considerations—all tempered by personal relationships—altered scientific representations of nature. Although historians have long considered Romanticism at best a minor tributary to scientific thought, Richards moves it to the center of the main currents of nineteenth-century biology, culminating in the conception of nature that underlies Darwin's evolutionary theory. Uniting the personal and poetic aspects of philosophy and science in a way that the German Romantics themselves would have honored, The Romantic Conception of Life alters how we look at Romanticism and nineteenth-century biology. (shrink)

Human Nature After Darwin is an original investigation of the implications of Darwinism for our understanding of ourselves and our situation. It casts new light on current Darwinian controversies, and in doing so provides an introduction to philosophical reasoning and a range of philosophical problems. Janet Radcliffe Richards claims that many current battles about Darwinism, in particular about evolutionary psychology and religion, are based on mistaken assumptions about the implications of the rival views. Her analysis of these implications provides (...) a much-needed guide to the fundamentals of Darwinism and the so-called Darwin-wars, as well as providing a set of philosophical techniques relevant to wide areas of moral and political debate. It also raises philosophical problems of knowledge and certainly, free will and responsibility, altruism, the status of ethics, and the relevance of Darwinism to questions of ethics, politics and religion. The lucid presentation makes the book an ideal introduction to both philosophy and Darwinism, as well as a substantive contribution to topics of intense current controversy. It will be of interest to students of philosophy, science and the social sciences, and critical thinking. (shrink)

_Human Nature After Darwin_ is an original investigation of the implications of Darwinism for our understanding of ourselves and our situation. It casts new light on current Darwinian controversies, also providing an introduction to philosophical reasoning and a range of philosophical problems. Janet Radcliffe Richards claims that many current battles about Darwinism are based on mistaken assumptions about the implications of the rival views. Her analysis of these implications provides a much-needed guide to the fundamentals of Darwinism and the so-called (...) Darwin wars, as well as providing a set of philosophical techniques relevant to wide areas of moral and political debate. The lucid presentation makes the book an ideal introduction to both philosophy and Darwinism as well as a substantive contribution to topics of intense current controversy. It will be of interest to students of philosophy, science and the social sciences, and critical thinking. (shrink)

_Human Nature After Darwin_ is an original investigation of the implications of Darwinism for our understanding of ourselves and our situation. It casts new light on current Darwinian controversies, also providing an introduction to philosophical reasoning and a range of philosophical problems. Janet Radcliffe Richards claims that many current battles about Darwinism are based on mistaken assumptions about the implications of the rival views. Her analysis of these implications provides a much-needed guide to the fundamentals of Darwinism and the so-called (...) Darwin wars, as well as providing a set of philosophical techniques relevant to wide areas of moral and political debate. The lucid presentation makes the book an ideal introduction to both philosophy and Darwinism as well as a substantive contribution to topics of intense current controversy. It will be of interest to students of philosophy, science and the social sciences, and critical thinking. (shrink)